SYNVISC-ONE® (hylan G-F 20) is a single-injection viscosupplement formulated to provide long-lasting relief from knee osteoarthritis pain. Designed to mimic and supplement the natural synovial fluid in the joint, SYNVISC-ONE® enhances lubrication, improves shock absorption, and reduces friction to support smoother, more comfortable movement with just one treatment session.

Key Benefits
• Single-injection treatment for convenience and patient comfort
• Long-lasting pain relief for knee osteoarthritis
• High-viscosity hylan formulation for superior cushioning
• Helps restore natural joint lubrication and mobility
• Non-surgical option for patients who haven’t responded to oral medications

How It Works
SYNVISC-ONE® contains hylan polymers that closely resemble the hyaluronan naturally found in healthy synovial fluid. When injected into the knee joint, the gel-like solution improves viscosity and elasticity, providing enhanced cushioning and reducing mechanical stress. This leads to decreased pain and improved joint function over time.

Ideal Candidates
Adults with knee osteoarthritis experiencing persistent pain, stiffness, or reduced mobility despite conservative treatments such as oral analgesics, physical therapy, or lifestyle changes. Ideal for patients looking for a long-lasting, minimally invasive alternative to surgery.

Administration
Administered as a single intra-articular injection into the knee by a licensed medical professional. Many patients experience pain relief within weeks, with benefits often lasting up to six months or longer, depending on individual factors and lifestyle.

Possible Side Effects
Typical side effects may include temporary joint swelling, stiffness, warmth, or discomfort. Mild localized inflammation can occur but usually resolves quickly. Serious adverse reactions are rare, especially when performed by an experienced practitioner.