Restylane Defyne is an injectable, viscoelastic gel containing non-animal, cross-linked hyaluronic acid and Lidocaine, for pain relief. Restylane Defyne is suitable for use as a dermal filler to correct deep wrinkles, folds, or other skin defects when injected into the deep dermis or upper subcutaneous layer. Results of a Restylane Defyne treatment usually last about 6 to 9 months, and sometimes as long as 12 months. Only authorized personnel, in accordance with local legislation, should administer Restylane Defyne.