DUROLANE® is a highly purified, non-animal stabilized hyaluronic acid (NASHA®) viscoelastic gel used for the treatment of knee osteoarthritis pain in patients who have not achieved adequate relief from conservative therapies. Each pre-filled 3 mL syringe contains 20 mg of stabilized sodium hyaluronate, designed to restore joint lubrication and shock absorption for smoother, more comfortable movement.

DUROLANE® is known for its single-injection treatment approach, allowing convenience and long-lasting symptom relief without repeated weekly injections.

Key Benefits

• Single-dose viscosupplement for knee osteoarthritis

• Helps reduce pain and improve mobility

• Restores synovial fluid viscosity and cushioning

• Non-animal derived — lower immunogenic potential

• May delay or reduce the need for surgical intervention

• Clinically proven sustained relief with one injection

How It Works
The NASHA® technology maintains a long-residence hyaluronic acid gel inside the joint, enhancing synovial fluid function and providing protective cushioning. This helps reduce friction on cartilage and supports more comfortable joint activity.

Ideal Candidates

• Adults with symptomatic knee osteoarthritis

• Patients seeking non-opioid, nonsurgical pain management

• Those preferring a single-injection treatment option

Administration

• Packaged as 1 × 3 mL pre-filled syringe

• Injected intra-articularly by a qualified healthcare professional

• Benefits often visible within weeks, with long-lasting relief

Possible Side Effects

• Mild swelling, discomfort, or warmth at the injection site

• Temporary stiffness or joint effusion may occur

• Rare inflammatory or hypersensitivity reactions