CRESPINE® GEL PLUS is an advanced hyaluronic acid (HA) viscosupplement designed to restore lubrication and cushioning within joints affected by osteoarthritis. Formulated as a highly concentrated, cross-linked HA gel, it provides long-lasting support to reduce pain, improve mobility, and enhance overall joint function with a single-injection approach.

Key Benefits
• Long-lasting pain relief for osteoarthritic joints
• Cross-linked hyaluronic acid offers extended durability and cushioning
• Single-injection treatment for convenience and patient comfort
• Helps restore joint lubrication and reduce friction during movement
• Non-surgical solution for patients not responding to oral medications

How It Works
CRESPINE® GEL PLUS contains a viscoelastic HA gel that mimics the natural synovial fluid within healthy joints. When injected into the intra-articular space, it enhances lubrication, improves shock absorption, and reduces mechanical stress on the joint surfaces. The cross-linked structure ensures longer persistence, providing sustained pain relief and improved mobility.

Ideal Candidates
Adults with mild to moderate osteoarthritis experiencing persistent joint pain or stiffness, especially those seeking a minimally invasive alternative to oral analgesics or surgical intervention. Suitable for individuals looking for longer-term relief with a single treatment session.

Common Treatment Areas Include:
• Knee joint
• Hip joint
• Shoulder joint
• Other synovial joints as clinically indicated

Administration
Administered as a single intra-articular injection by a licensed medical professional. Its cross-linked HA formulation provides prolonged residence time within the joint. Pain relief and improved mobility may be noticed within days, with benefits often lasting several months depending on patient factors.

Possible Side Effects
Temporary swelling, discomfort, warmth, or mild joint stiffness may occur at the injection site. Rarely, joint effusion or inflammatory responses may develop. Side effects are typically mild and resolve with standard post-treatment care.