How does Azzalure work?
Azzalure is a therapeutic protein made of botulinum toxin type A and is indicated for the treatment of dynamic wrinkles in the face. Dynamic wrinkles are skin depressions that are usually attributed to facial movement such as laughing, eating, or frowning. In some instances, these wrinkles may become severe or persist as the skin ages and loses its laxity. Botulinum toxin is able to temporarily improve the appearance of dynamic wrinkles by preventing the underlying facial muscles from contracting. When injected into the muscle, this neurotoxin accumulates at the neuromuscular junction (junction between nerves and muscle) where it prevents the release of acetylcholine, a neurotransmitter involved in the conduction of nerve signaling. As a result, the affected muscle relaxes, smoothing out any wrinkles in the overlying skin. This mechanism of action is temporary and will need to be repeated in order to maintain the results.
How long does Azzalure last?
Patients should notice an improvement in the appearance of the treated site (either glabellar lines or lateral canthal lines) within 2–3 days after treatment, with maximum effect seen a month after treatment. Studies have shown that the results of Azzalure can last for up to 4 months after treatment, after which a repeat treatment is necessary to maintain the effects. The frequency of repeat injections will be determined by assessment of the individual response of the patient to treatment, but should not be repeated more often than every 12 weeks.