Synvisc® Classic is a viscosupplement used to relieve pain in patients with knee osteoarthritis who have not achieved sufficient relief from conservative therapy. Each box contains three single-use 2 mL pre-filled syringes of Hylan G-F 20, a highly purified, elastoviscous hyaluronan-based gel designed to supplement depleted synovial fluid within the joint.

By improving joint lubrication, shock absorption, and biomechanical motion, Synvisc® Classic helps reduce pain and enhance mobility — offering a non-surgical option for symptom management.

Key Benefits

• Effective pain relief for knee osteoarthritis

• Improves joint lubrication and cushioning

• Can enhance mobility and functional activity

• Long-lasting relief with a short treatment regimen

• Non-systemic therapy suitable for many patient types

Administration

• Packaged as 3 × 2 mL pre-filled syringes

• Administered via one injection per week for 3 weeks

• For intra-articular use only and must be injected by a trained healthcare professional

How It Works
The Hylan G-F 20 formulation mimics the natural hyaluronic acid found in healthy synovial fluid. It helps restore the joint’s ability to lubricate, protect cartilage, and absorb impact — reducing pain caused by movement and weight-bearing.

Ideal Candidates

• Adults with symptomatic knee osteoarthritis

• Those seeking non-opioid, non-surgical pain management

• Patients with inadequate response to NSAIDs or physical therapy

Possible Side Effects

• Temporary swelling, pain, or warmth at the injection site

• Mild joint stiffness or small effusion may occur

• Rare risk of inflammatory reactions